Center for Companion Animal Studies

Kenneth W. Smith Professorship

Participating Faculty Members

Infectious Disease Assays

Current Studies

PVM Student Projects

Companion Animal Studies Award

Corporate Sponsors

Shelter Collaborations

Blood Donor Program

Donations

Chelsea and Mr. Dickens

Home

The Center for Companion Animal Studies at Colorado State University has shown that cats vaccinated with FVRCP vaccines grown on Crandell-Rees Feline Kidney (CRFK) cell lines can develop antibodies to renal proteins, and that cats hypersensitized to CRFK cell lysates can develop interstitial nephritis. The immunodominat antigens to which antibodies are formed in these cats are α-enolase and Annexin A2, both of which are linked to autoimmunity and renal disease in humans. Recently, we have shown that cats administered FVRCP vaccines parenterally have higher levels of circulating antibodies to these antigens than do cats who were administered a FVRCP vaccine for intranasal administration. We now have funding from the Morris Animal Foundation to study the presence of antibodies to α-enolase and Annexin A2 in azotemic and non-azotemic cats with known vaccine history. We are seeking blood samples from patients with a minimum of 5 years of vaccination history available. Qualified patients will receive a free serum biochemistry analysis and will help discover the cause of this frustrating syndrome. Please visit the following links for further information and forms to be used with the study.

Client Consent

Standard Operating Procedure

Submission form

Supporting manuscripts:

"CRFK and renal antibodies in vaccinated cats"

"Interstitial nephritis in CRFK hypersensitized cats"

"Antibodies against alpha enolase and annexin A2"